Gene set meta-analysis with Quantitative Set Analysis for Gene Expression (QuSAGE).
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ABSTRACT:
SUBMITTER: Meng H
PROVIDER: S-EPMC6461294 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Gene set meta-analysis with Quantitative Set Analysis for Gene Expression (QuSAGE).
Meng Hailong H Yaari Gur G Bolen Christopher R CR Avey Stefan S Kleinstein Steven H SH
PLoS computational biology 20190402 4
Small sample sizes combined with high person-to-person variability can make it difficult to detect significant gene expression changes from transcriptional profiling studies. Subtle, but coordinated, gene expression changes may be detected using gene set analysis approaches. Meta-analysis is another approach to increase the power to detect biologically relevant changes by integrating information from multiple studies. Here, we present a framework that combines both approaches and allows for meta ...[more]
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