Unknown

Dataset Information

0

Validation of the Limiting Antigen Avidity Assay to Estimate Level and Trends in HIV Incidence in an A/D Epidemic in Rakai, Uganda.


ABSTRACT: The limiting-antigen avidity (LAg-Avidity) assay with viral load (VL) >1,000 copies/mL is being used to estimate population-level HIV incidence in Africa. However, this has not been validated in East Africa where HIV-1 subtypes A and D circulate. Sera from persons seen in two surveys (2008-2009 and 2012-2013) limited to those who attended the previous round of the Rakai Community Cohort in Uganda were analyzed. The performance of the current LAg-Avidity protocol, with a mean duration of recent infection (MDRI) of 130 days and false recent rate (FRR) of 0%, was compared with subtype-specific MDRI and FRR, adjusted to subtype distributions. The observed incidence was 1.05/100 person years (py) [95% confidence interval (CI) 0.90-1.23] in 2008-2009 and 0.66/100?py (95% CI 0.52-0.83) in 2012-2013. In contrast, the per-protocol LAg-Avidity incidence estimates were 1.63/100?py (95% CI 0.97-2.30) in 2008-2009 and 2.55/100?py (95% CI 1.51-3.59) in 2012-2013 (a significant increase, p?

SUBMITTER: Laeyendecker O 

PROVIDER: S-EPMC6461304 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications

Validation of the Limiting Antigen Avidity Assay to Estimate Level and Trends in HIV Incidence in an A/D Epidemic in Rakai, Uganda.

Laeyendecker Oliver O   Gray Ronald H RH   Grabowski M Kate MK   Reynolds Steven J SJ   Ndyanabo Anthony A   Ssekasanvu Joseph J   Fernandez Reinaldo E RE   Wawer Maria J MJ   Serwadda David D   Quinn Thomas C TC  

AIDS research and human retroviruses 20190129 4


The limiting-antigen avidity (LAg-Avidity) assay with viral load (VL) >1,000 copies/mL is being used to estimate population-level HIV incidence in Africa. However, this has not been validated in East Africa where HIV-1 subtypes A and D circulate. Sera from persons seen in two surveys (2008-2009 and 2012-2013) limited to those who attended the previous round of the Rakai Community Cohort in Uganda were analyzed. The performance of the current LAg-Avidity protocol, with a mean duration of recent i  ...[more]

Similar Datasets

| S-EPMC4981313 | biostudies-literature
| S-EPMC6746377 | biostudies-literature
| S-EPMC7900440 | biostudies-literature
| S-EPMC6660077 | biostudies-literature
| S-EPMC5110383 | biostudies-literature
| S-EPMC7458132 | biostudies-literature
| S-EPMC3415936 | biostudies-literature
| S-EPMC4973864 | biostudies-literature
| S-EPMC5027874 | biostudies-literature
| S-EPMC4746783 | biostudies-literature