Ontology highlight
ABSTRACT:
SUBMITTER: Lodge EJ
PROVIDER: S-EPMC6461440 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Lodge Emily J EJ Santambrogio Alice A Russell John P JP Xekouki Paraskevi P Jacques Thomas S TS Johnson Randy L RL Thavaraj Selvam S Bornstein Stefan R SR Andoniadou Cynthia Lilian CL
eLife 20190326
SOX2 positive pituitary stem cells (PSCs) are specified embryonically and persist throughout life, giving rise to all pituitary endocrine lineages. We have previously shown the activation of the STK/LATS/YAP/TAZ signalling cascade in the developing and postnatal mammalian pituitary. Here, we investigate the function of this pathway during pituitary development and in the regulation of the SOX2 cell compartment. Through loss- and gain-of-function genetic approaches, we reveal that restricting YAP ...[more]