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Hospitalization, surgery, and incident dementia.


ABSTRACT: INTRODUCTION:We evaluated whether hospitalization with or without surgery increases risk for dementia or Alzheimer's disease. METHODS:A clinical sample (843 clinically diagnosed dementia cases; 1686 matched nondemented individuals) was identified from Swedish Twin Registry studies. A register-based sample (4293 cases; 21,465 matched controls) was identified by linkage of Swedish Twin Registry to Swedish Patient Registry records. Apolipoprotein E (APOE) status and within-pair comparisons of dementia discordant twins indicated genetic susceptibility. RESULTS:Nonsurgical hospitalization is associated with greater dementia risk than hospitalization with surgical intervention. In the register sample, thoracic, abdominal, and major orthopedic procedures entailed dementia risk; in the clinical sample, orthopedic alone. Within-pair analyses indicate that associations in part reflect genetic susceptibility in common to hospitalization and dementia. Potential gene-environment interactions were indicated by greater risk due to hospitalization among APOE ?4 noncarriers. DISCUSSION:We confirm hospitalization as a risk factor for dementia, with repeated hospitalizations a more important risk factor than surgery.

SUBMITTER: Eriksson LI 

PROVIDER: S-EPMC6461518 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Hospitalization, surgery, and incident dementia.

Eriksson Lars I LI   Lundholm Cecilia C   Narasimhalu Kaavya K   Sandin Rolf R   Jin Ya-Ping YP   Gatz Margaret M   Pedersen Nancy L NL  

Alzheimer's & dementia : the journal of the Alzheimer's Association 20190215 4


<h4>Introduction</h4>We evaluated whether hospitalization with or without surgery increases risk for dementia or Alzheimer's disease.<h4>Methods</h4>A clinical sample (843 clinically diagnosed dementia cases; 1686 matched nondemented individuals) was identified from Swedish Twin Registry studies. A register-based sample (4293 cases; 21,465 matched controls) was identified by linkage of Swedish Twin Registry to Swedish Patient Registry records. Apolipoprotein E (APOE) status and within-pair compa  ...[more]

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