Hospitalization, surgery, and incident dementia.
Ontology highlight
ABSTRACT: Introduction
We evaluated whether hospitalization with or without surgery increases risk for dementia or Alzheimer's disease.Methods
A clinical sample (843 clinically diagnosed dementia cases; 1686 matched nondemented individuals) was identified from Swedish Twin Registry studies. A register-based sample (4293 cases; 21,465 matched controls) was identified by linkage of Swedish Twin Registry to Swedish Patient Registry records. Apolipoprotein E (APOE) status and within-pair comparisons of dementia discordant twins indicated genetic susceptibility.Results
Nonsurgical hospitalization is associated with greater dementia risk than hospitalization with surgical intervention. In the register sample, thoracic, abdominal, and major orthopedic procedures entailed dementia risk; in the clinical sample, orthopedic alone. Within-pair analyses indicate that associations in part reflect genetic susceptibility in common to hospitalization and dementia. Potential gene-environment interactions were indicated by greater risk due to hospitalization among APOE ε4 noncarriers.Discussion
We confirm hospitalization as a risk factor for dementia, with repeated hospitalizations a more important risk factor than surgery.
SUBMITTER: Eriksson LI
PROVIDER: S-EPMC6461518 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Hospitalization, surgery, and incident dementia.
Eriksson Lars I LI Lundholm Cecilia C Narasimhalu Kaavya K Sandin Rolf R Jin Ya-Ping YP Gatz Margaret M Pedersen Nancy L NL
Alzheimer's & dementia : the journal of the Alzheimer's Association 20190215 4
<h4>Introduction</h4>We evaluated whether hospitalization with or without surgery increases risk for dementia or Alzheimer's disease.<h4>Methods</h4>A clinical sample (843 clinically diagnosed dementia cases; 1686 matched nondemented individuals) was identified from Swedish Twin Registry studies. A register-based sample (4293 cases; 21,465 matched controls) was identified by linkage of Swedish Twin Registry to Swedish Patient Registry records. Apolipoprotein E (APOE) status and within-pair compa ...[more]
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