Dataset Information

Patients with Alzheimer's disease who carry the APOE ?4 allele benefit more from physical exercise.

ABSTRACT: Introduction:Our group has completed an exercise study of 200 patients with mild Alzheimer's disease. We found improvements in cognitive, neuropsychiatric, and physical measures in the participants who adhered to the protocol. Epidemiological studies in healthy elderly suggest that exercise preserves cognitive and physical abilities to a higher extent in AP OE ?4 carriers. Methods:In this post hoc subgroup analysis study, we investigated whether the beneficial effect of an exercise intervention in patients with mild AD was dependent on the patients' APOE genotype. Results:We found that patients who were APOE ?4 carriers benefitted more from the exercise intervention by preservation of cognitive performance and improvement in physical measures. Discussion:This exploratory study establishes a possible connection between the beneficial effects of exercise in AD and the patients' APOE genotype. These findings, if validated, could greatly impact the clinical management of patients with AD and those at risk for developing AD.

SUBMITTER: Jensen CS

PROVIDER: S-EPMC6461575 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Patients with Alzheimer's disease who carry the <i>APOE</i> ε4 allele benefit more from physical exercise.

Jensen Camilla Steen CS Simonsen Anja Hviid AH Siersma Volkert V Beyer Nina N Frederiksen Kristian Steen KS Gottrup Hanne H Hoffman Kristine K Høgh Peter P Frikke-Schmidt Ruth R Sobol Nanna Aue NA Waldemar Gunhild G Wermuth Lene L Hasselbalch Steen Gregers SG

Alzheimer's & dementia (New York, N. Y.) 20190408

<h4>Introduction</h4>Our group has completed an exercise study of 200 patients with mild Alzheimer's disease. We found improvements in cognitive, neuropsychiatric, and physical measures in the participants who adhered to the protocol. Epidemiological studies in healthy elderly suggest that exercise preserves cognitive and physical abilities to a higher extent in <i>AP</i> <i>OE</i> ε4 carriers.<h4>Methods</h4>In this post hoc subgroup analysis study, we investigated whether the beneficial effect ...[more]

PMID: 31011620

Similar Datasets

Project description:BackgroundLeukocyte telomere length (LTL) has been shown to predict Alzheimer's disease (AD), albeit inconsistently. Failing to account for the competing risks between AD, other dementia types, and mortality, can be an explanation for the inconsistent findings in previous time-to-event analyses. Furthermore, previous studies indicate that the association between LTL and AD is non-linear and may differ depending on apolipoprotein E (APOE) ε4 allele carriage, the strongest genetic AD predictor.MethodsWe analyzed whether baseline LTL in interaction with APOE ε4 predicts AD, by following 1306 initially non-demented subjects for 25 years. Gender- and age-residualized LTL (rLTL) was categorized into tertiles of short, medium, and long rLTLs. Two complementary time-to-event models that account for competing risks were used; the Fine-Gray model to estimate the association between the rLTL tertiles and the cumulative incidence of AD, and the cause-specific hazard model to assess whether the cause-specific risk of AD differed between the rLTL groups. Vascular dementia and death were considered competing risk events. Models were adjusted for baseline lifestyle-related risk factors, gender, age, and non-proportional hazards.ResultsAfter follow-up, 149 were diagnosed with AD, 96 were diagnosed with vascular dementia, 465 died without dementia, and 596 remained healthy. Baseline rLTL and other covariates were assessed on average 8 years before AD onset (range 1-24). APOE ε4-carriers had significantly increased incidence of AD, as well as increased cause-specific AD risk. A significant rLTL-APOE interaction indicated that short rLTL at baseline was significantly associated with an increased incidence of AD among non-APOE ε4-carriers (subdistribution hazard ratio = 3.24, CI 1.404-7.462, P = 0.005), as well as borderline associated with increased cause-specific risk of AD (cause-specific hazard ratio = 1.67, CI 0.947-2.964, P = 0.07). Among APOE ε4-carriers, short or long rLTLs were not significantly associated with AD incidence, nor with the cause-specific risk of AD.ConclusionsOur findings from two complementary competing risk time-to-event models indicate that short rLTL may be a valuable predictor of the AD incidence in non-APOE ε4-carriers, on average 8 years before AD onset. More generally, the findings highlight the importance of accounting for competing risks, as well as the APOE status of participants in AD biomarker research.

Dataset Information

Patients with Alzheimer's disease who carry the APOE ?4 allele benefit more from physical exercise.

Publications

Patients with Alzheimer's disease who carry the <i>APOE</i> ε4 allele benefit more from physical exercise.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets