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Greater tuberosity angle and critical shoulder angle according to the delamination patterns of rotator cuff tear.

ABSTRACT: The purpose was to evaluate the relationship between GTA, CSA, and the delamination patterns of RCTs. This study included 315 patients with RCTs from 2014 to 2018, retrospectively. The subjects were divided into 5 groups: Group A, control group; Group B, non-delaminated tear; Group C, delaminated tear with equally retraction of articular and bursal layer; Group D, articular layer more retracted delaminated tear, and Group E, bursal layer more retracted delaminated tear. In conclusion, large GTA and CSA were associated with rotator cuff tears. However, there was no difference of GTA and CSA according to the delamination patterns.

SUBMITTER: Yoo JS

PROVIDER: S-EPMC6461600 | biostudies-literature | 2019 Sep-Oct

REPOSITORIES: biostudies-literature

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Greater tuberosity angle and critical shoulder angle according to the delamination patterns of rotator cuff tear.

Yoo Jae-Sung JS Heo Kang K Yang Jong-Heon JH Seo Joong-Bae JB

Journal of orthopaedics 20190408 5

The purpose was to evaluate the relationship between GTA, CSA, and the delamination patterns of RCTs. This study included 315 patients with RCTs from 2014 to 2018, retrospectively. The subjects were divided into 5 groups: Group A, control group; Group B, non-delaminated tear; Group C, delaminated tear with equally retraction of articular and bursal layer; Group D, articular layer more retracted delaminated tear, and Group E, bursal layer more retracted delaminated tear. In conclusion, large GTA ...[more]

PMID: 31011247

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Project description:Myosteatosis is the pathological accumulation of lipid that occurs in conjunction with atrophy and fibrosis following skeletal muscle injury or disease. Little is known about the mechanisms by which lipid accumulates in myosteatosis, but many studies have demonstrated the degree of lipid infiltration negatively correlates with muscle function and regeneration. Our goal was to identify biochemical pathways that lead to muscle dysfunction and lipid accumulation in injured rotator cuff muscles, a model that demonstrates severe myosteatosis. Adult rats were subjected to a massive tear to the rotator cuff musculature. After a period of either 0 (healthy control), 10, 30, or 60 days, muscles were prepared for RNA sequencing, shotgun lipidomics, metabolomics, biochemical measures, electron microscopy, and muscle fiber contractility. Following rotator cuff injury, there was a decrease in muscle fiber specific force production that was lowest at 30d. There was a dramatic time dependent increase in triacylglyceride content. Interestingly, genes related to not only triacylglyceride synthesis, but also lipid oxidation were largely downregulated over time. Using bioinformatics techniques, we identified that biochemical pathways related to mitochondrial dysfunction and reactive oxygen species were considerably increased in muscles with myosteatosis. Long chain acyl-carnitines and L-carnitine, precursors to beta-oxidation, were depleted following rotator cuff tear. Electron micrographs showed injured muscles displayed large lipid droplets within mitochondria at early time points, and an accumulation of peripheral segment mitochondria at all time points. Several markers of oxidative stress were elevated following rotator cuff tear. The results from this study suggest that the accumulation of lipid in myosteatosis is not a result of canonical lipid synthesis, but occurs due to decreased lipid oxidation in mitochondria. A failure in lipid utilization by mitochondria would ultimately cause an accumulation of lipid even in the absence of increased synthesis. Further study will identify whether this process is required for the onset of myosteatosis.

Dataset Information

Greater tuberosity angle and critical shoulder angle according to the delamination patterns of rotator cuff tear.

Publications

Greater tuberosity angle and critical shoulder angle according to the delamination patterns of rotator cuff tear.

Similar Datasets

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