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Multimodal MRI evaluation of parkinsonian limbic pathologies.


ABSTRACT: Previous multimodal magnetic resonance imaging (MRI) studies of parkinsonian syndromes have focused primarily on motor-related basal ganglia structures. The present study investigated MRI changes in nonmotor-related limbic structures in 35 Parkinson's disease, 16 multiple system atrophy parkinsonian subtype, 17 progressive supranuclear palsy, and 37 control subjects. Mean diffusivity (MD), fractional anisotropy, transverse relaxation rate (R2*), quantitative susceptibility mapping, and volume measurements were obtained from the amygdala, hippocampus, and nucleus accumbens (NAc) to examine differences between groups and to test for associations with clinical scores. Compared with controls, Parkinson's disease subjects had lower NAc volume; multiple system atrophy parkinsonian subtype subjects had higher NAc transverse relaxation rate; and progressive supranuclear palsy subjects had higher amygdala and hippocampus MD and lower hippocampus fractional anisotropy (p's ? 0.008). Among parkinsonian subjects, amygdala and hippocampus MD associated positively with Unified Parkinson's Disease Rating Scale nonmotor and activities of daily living scores (p's ? 0.005). Together, these findings support the inclusion of limbic structures in future MRI studies of parkinsonian syndromes.

SUBMITTER: Wang EW 

PROVIDER: S-EPMC6461740 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Multimodal MRI evaluation of parkinsonian limbic pathologies.

Wang Ernest W EW   Du Guangwei G   Lewis Mechelle M MM   Lee Eun-Young EY   De Jesus Sol S   Kanekar Sangam S   Kong Lan L   Huang Xuemei X  

Neurobiology of aging 20190116


Previous multimodal magnetic resonance imaging (MRI) studies of parkinsonian syndromes have focused primarily on motor-related basal ganglia structures. The present study investigated MRI changes in nonmotor-related limbic structures in 35 Parkinson's disease, 16 multiple system atrophy parkinsonian subtype, 17 progressive supranuclear palsy, and 37 control subjects. Mean diffusivity (MD), fractional anisotropy, transverse relaxation rate (R2*), quantitative susceptibility mapping, and volume me  ...[more]

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