Ability of swept source OCT to detect retinal changes in patients with bipolar disorder.

ABSTRACT: PURPOSE:To evaluate the ability of swept source optical coherence tomography (SS-OCT) to detect retinal changes in patients with bipolar disorder (BD). METHODS:Twenty-three patients with BD and 23 controls underwent retinal evaluation using SS deep range imaging (DRI) Triton OCT. Full retinal thickness, the ganglion cell layer (GCL), the retinal nerve fiber layer (RNFL), and choroidal thickness were evaluated with automated segmentation software. RESULTS:Patients with BD were shown to have significant thinning of the macular full retinal thickness in the center (p?=?0.049), inner temporal (p?=?0.045), inner nasal (p?=?0.016), and inner inferior (p?=?0.016) of the ETDRS areas. The macular GCL layer was reduced in patients compared with controls (average, p?=?0.002; superior, p?=?0.009; superonasal, p?=?0.009; inferonasal, p?=?0.003; and inferior, p?=?0.009). Peripapillary reduction of full retinal thickness (average, p?

SUBMITTER: Polo V 

PROVIDER: S-EPMC6461914 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature