Diet quality and Gleason grade progression among localised prostate cancer patients on active surveillance.

ABSTRACT:

Background

High diet quality may support a metabolic and anti-inflammatory state less conducive to tumour progression. We prospectively investigated diet quality in relation to Gleason grade progression among localised prostate cancer patients on active surveillance, a clinical management strategy of disease monitoring and delayed intervention.

Methods

Men with newly diagnosed Gleason score 6 or 7 prostate cancer enroled on a biennial monitoring regimen. Patients completed a food frequency questionnaire (FFQ) at baseline (n = 411) and first 6-month follow-up (n = 263). Cox proportional hazards models were fitted to evaluate multivariable-adjusted associations of diet quality [defined via the Healthy Eating Index (HEI)-2015] with Gleason grade progression.

Results

Afte

SUBMITTER: Gregg JR 

PROVIDER: S-EPMC6462004 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature