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Salmonella SiiE prevents an efficient humoral immune memory by interfering with IgG+ plasma cell persistence in the bone marrow.


ABSTRACT: Serum IgG, which is mainly generated from IgG-secreting plasma cells in the bone marrow (BM), protects our body against various pathogens. We show here that the protein SiiE of Salmonella is both required and sufficient to prevent an efficient humoral immune memory against the pathogen by selectively reducing the number of IgG-secreting plasma cells in the BM. Attenuated SiiE-deficient Salmonella induces high and lasting titers of specific and protective Salmonella-specific IgG and qualifies as an efficient vaccine against Salmonella A SiiE-derived peptide with homology to laminin ?1 is sufficient to ablate IgG-secreting plasma cells from the BM, identifying laminin ?1 as a component of niches for IgG-secreting plasma cells in the BM, and furthermore, qualifies it as a unique therapeutic option to selectively ablate IgG-secreting plasma cells in autoimmune diseases and multiple myeloma.

SUBMITTER: Manne C 

PROVIDER: S-EPMC6462062 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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<i>Salmonella</i> SiiE prevents an efficient humoral immune memory by interfering with IgG<sup>+</sup> plasma cell persistence in the bone marrow.

Männe Christian C   Takaya Akiko A   Yamasaki Yuzuru Y   Mursell Mathias M   Hojyo Shintaro S   Wu Tsung-Yen TY   Sarkander Jana J   McGrath Mairi A MA   Cornelis Rebecca R   Hahne Stefanie S   Cheng Qingyu Q   Kawamoto Tadafumi T   Hiepe Falk F   Kaufmann Stefan H E SHE   Yamamoto Tomoko T   Radbruch Andreas A   Tokoyoda Koji K  

Proceedings of the National Academy of Sciences of the United States of America 20190325 15


Serum IgG, which is mainly generated from IgG-secreting plasma cells in the bone marrow (BM), protects our body against various pathogens. We show here that the protein SiiE of <i>Salmonella</i> is both required and sufficient to prevent an efficient humoral immune memory against the pathogen by selectively reducing the number of IgG-secreting plasma cells in the BM. Attenuated SiiE-deficient <i>Salmonella</i> induces high and lasting titers of specific and protective <i>Salmonella</i>-specific  ...[more]

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