PAM3 supports the generation of M2-like macrophages from lupus patient monocytes and improves disease outcome in murine lupus.
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ABSTRACT:
SUBMITTER: Horuluoglu B
PROVIDER: S-EPMC6462249 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
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PAM3 supports the generation of M2-like macrophages from lupus patient monocytes and improves disease outcome in murine lupus.
Horuluoglu Begum B Bayik Defne D Kayraklioglu Neslihan N Goguet Emilie E Kaplan Mariana J MJ Klinman Dennis M DM
Journal of autoimmunity 20190122
Systematic Lupus Erythematosus (SLE) is an autoimmune syndrome of unclear etiology. While T and B cell abnormalities contribute to disease pathogenesis, recent work suggests that inflammatory M1-like macrophages also play a role. Previous work showed that the TLR2/1 agonist PAM3CSK4 (PAM3) could stimulate normal human monocytes to preferentially differentiate into immunosuppressive M2-like rather than inflammatory M1-like macrophages. This raised the possibility of PAM3 being used to normalize t ...[more]
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