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The biological embedding of early-life socioeconomic status and family adversity in children's genome-wide DNA methylation.

ABSTRACT: AIM:To examine variation in child DNA methylation to assess its potential as a pathway for effects of childhood social adversity on health across the life course. MATERIALS & METHODS:In a diverse, prospective community sample of 178 kindergarten children, associations between three types of social experience and DNA methylation within buccal epithelial cells later in childhood were examined. RESULTS:Family income, parental education and family psychosocial adversity each associated with increased or decreased DNA methylation (488, 354 and 102 sites, respectively) within a unique set of genomic CpG sites. Gene ontology analyses pointed to genes serving immune and developmental regulation functions. CONCLUSION:Findings provided support for DNA methylation as a biomarker linking early-life social experiences with later life health in humans.

SUBMITTER: Bush NR 

PROVIDER: S-EPMC6462839 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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The biological embedding of early-life socioeconomic status and family adversity in children's genome-wide DNA methylation.

Bush Nicole R NR   Edgar Rachel D RD   Park Mina M   MacIsaac Julia L JL   McEwen Lisa M LM   Adler Nancy E NE   Essex Marilyn J MJ   Kobor Michael S MS   Boyce W Thomas WT  

Epigenomics 20181023 11

<h4>Aim</h4>To examine variation in child DNA methylation to assess its potential as a pathway for effects of childhood social adversity on health across the life course.<h4>Materials & methods</h4>In a diverse, prospective community sample of 178 kindergarten children, associations between three types of social experience and DNA methylation within buccal epithelial cells later in childhood were examined.<h4>Results</h4>Family income, parental education and family psychosocial adversity each as  ...[more]

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