Dataset Information
Molecular pathogenesis of disease progression in MLL-rearranged AML.
Ontology highlight
ABSTRACT:
SUBMITTER: Kotani S
PROVIDER: S-EPMC6462875 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Molecular pathogenesis of disease progression in MLL-rearranged AML.
Leukemia 20180912 3
Leukemic relapse is frequently accompanied by progressively aggressive clinical course. To understand the molecular mechanism of leukemic relapse, MLL/AF9-transformed mouse leukemia cells were serially transplanted in C57BL/6 mice (N = 96) by mimicking repeated recurrences, where mutations were monitored by exome sequencing (N = 42). The onset of leukemia was progressively promoted with advanced transplants, during which increasing numbers of somatic mutations were acquired (P < 0.005). Among th ...[more]
