Molecular pathogenesis of disease progression in MLL-rearranged AML.
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ABSTRACT:
SUBMITTER: Kotani S
PROVIDER: S-EPMC6462875 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Molecular pathogenesis of disease progression in MLL-rearranged AML.
Kotani Shinichi S Yoda Akinori A Kon Ayana A Kataoka Keisuke K Ochi Yotaro Y Shiozawa Yusuke Y Hirsch Cassandra C Takeda June J Ueno Hiroo H Yoshizato Tetsuichi T Yoshida Kenichi K Nakagawa Masahiro M MM Nannya Yasuhito Y Kakiuchi Nobuyuki N Yamauchi Takuji T Aoki Kosuke K Shiraishi Yuichi Y Miyano Satoru S Maeda Takahiro T Maciejewski Jaroslaw P JP Takaori-Kondo Akifumi A Ogawa Seishi S Makishima Hideki H
Leukemia 20180912 3
Leukemic relapse is frequently accompanied by progressively aggressive clinical course. To understand the molecular mechanism of leukemic relapse, MLL/AF9-transformed mouse leukemia cells were serially transplanted in C57BL/6 mice (N = 96) by mimicking repeated recurrences, where mutations were monitored by exome sequencing (N = 42). The onset of leukemia was progressively promoted with advanced transplants, during which increasing numbers of somatic mutations were acquired (P < 0.005). Among th ...[more]
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