Ontology highlight
ABSTRACT:
SUBMITTER: Lee JK
PROVIDER: S-EPMC6463520 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Lee John K JK Bosnakovski Darko D Toso Erik A EA Dinh Tracy T Banerjee Surajit S Bohl Thomas E TE Shi Ke K Orellana Kayo K Kyba Michael M Aihara Hideki H
Cell reports 20181201 11
Double homeobox (DUX) transcription factors are unique to eutherian mammals. DUX4 regulates expression of repetitive elements during early embryogenesis, but misexpression of DUX4 causes facioscapulohumeral muscular dystrophy (FSHD) and translocations overexpressing the DUX4 double homeodomain cause B cell leukemia. Here, we report the crystal structure of the tandem homeodomains of DUX4 bound to DNA. The homeodomains bind DNA in a head-to-head fashion, with the linker making anchoring DNA minor ...[more]