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Multiple infestations of gastrointestinal parasites - Probable cause for high mortality of Spot-billed Pelican (Pelecanus philippensis) at Kokrebellur Community Reserve, India.

ABSTRACT: We witnessed mortalities of Spot-billed Pelicans Pelecanus philippensis between December 2017 and May 2018 in Mandya and Mysuru districts of Karnataka, especially at Kokrebellur Community Reserve in Mandya district. The region has experienced severe drought in recent years with negligible water in all the water tanks. A total of 67 Spot-billed Pelicans died in five locations, of which 55 adult birds died at Kokrebellur. We collected four dead pelicans along with 97 fecal samples of live birds at Kokrebellur, water samples from nine water tanks around Kokrebellur, and six fish samples. We isolated the endoparasite eggs by following sedimentation and flotation technique, and counted the eggs from the water and fecal samples, and identified at the genus level using light microscope. We approximately counted the endoparasites by dissecting the fish and conducting a necropsy on dead pelicans. Endoparasite eggs were detected in seven of the nine water tanks. Each fish sample had at least 50-100 L3 stage worms of Contracaecum sp., and 880.0?±?459.3_SD of Contracaecum sp., worms in the digestive tracts and 60.0?±?36.5_SD worms of Echinostoma sp. in the intestine of the four dead pelicans. The endoparasite prevalence was 84.5% (N?=?83) with a mean abundance of 368.2?±?561.5_SD eggs/g in the fecal samples of live pelicans. Contracaecum sp., Echinostoma sp. and Opisthorchis viverrini were recorded in 51, 67 and nine fecal samples respectively. The high load of endoparasite eggs in the water tanks, an infestation of Contracaecum sp. in fishes and a heavy load of fully-grown worms of Contracaecum sp. and Echinostoma sp. in the adult pelicans are indicative of their high mortality in Kokrebellur Community Reserve. The coordinated program was initiated with the support of all stakeholders to control the endoparasites in water, fish, and pelicans.

SUBMITTER: Kumar S

PROVIDER: S-EPMC6463544 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Multiple infestations of gastrointestinal parasites - Probable cause for high mortality of Spot-billed Pelican (<i>Pelecanus philippensis</i>) at Kokrebellur Community Reserve, India.

Kumar Shanthala S Periyasamy A A Ranga Rao Nitin Venkatesh NV Sunil S S SS Kumara Honnavalli N HN Sundararaj P P Chidananda G G Sathish A A

International journal for parasitology. Parasites and wildlife 20190406

We witnessed mortalities of Spot-billed Pelicans <i>Pelecanus philippensis</i> between December 2017 and May 2018 in Mandya and Mysuru districts of Karnataka, especially at Kokrebellur Community Reserve in Mandya district. The region has experienced severe drought in recent years with negligible water in all the water tanks. A total of 67 Spot-billed Pelicans died in five locations, of which 55 adult birds died at Kokrebellur. We collected four dead pelicans along with 97 fecal samples of live b ...[more]

PMID: 31011528

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Project description:Although researchers have been trying to harness the immune system for over 100 years, the advent of immune checkpoint blockers (ICB) marks an era of significant clinical outcomes in various metastatic solid tumors, characterized by complete and durable responses. ICBs are monoclonal antibodies that target either of a pair of transmembrane molecules in tumors or T-cells involved in immune evasion. Currently 2 ICBs targeting the checkpoint program death 1 (PD-1), nivolumab and pembrolizumab, and one cytotoxic lymphocyte antigen-4 (CTLA-4) inhibitor (ipilimumab) are approved in gastrointestinal malignancies. We review herein the current evidence on predictive biomarkers for ICB response in gastrointestinal tumors. A review of literature based on the National Cancer Institute list of FDA-approved drugs for neoplasms and FDA-approved therapies at the FDA website was performed. An initial literature review was based on the American Association for Clinical Research meeting 2019, the American Society of Clinical Oncology meeting 2019 and the European Society of Medical Oncology 2019 proceedings. A systematic search of PubMed was performed involving MeSH browser terms such as biomarkers, immunotherapy, gastrointestinal diseases and neoplasms. When appropriate, American and British terms were used in the search. The most relevant predictor of response to ICBs is microsatellite instability (MSI) and the data is strongest for colorectal cancer. At least 3 prospective trials show evidence of PD-L1 as a predictive biomarker for ICB response in gastroesophageal malignancies. At least one prospective trial has described tumor mutational burden high (TMB-H), independent of MSI, as predictive of response in anal and biliary tract carcinomas. DNA Polymerase Epsilon (POLE) or delta (POL-D) mutations have been implicated in a subset of MSS colorectal cancer with TMB-H but this biomarker requires prospective validation. There is evolving data based on retrospective observations that gene alterations predicting acquired resistance and hyper-progression. Ongoing clinical research is assessing the role of the human microbiome and RNA-editing complex mutations as predictive biomarkers of response to ICBs. MSI has the strongest predictive power among current biomarkers for ICB response in gastrointestinal cancers. Data continue to accumulate from ongoing clinical trials and new biomarkers are emerging from pre-clinical studies, suggesting that drug combinations targeting pathways complimentary to the PD-1/PD-L1 axis inhibition will define a robust field of clinical research.

Dataset Information

Multiple infestations of gastrointestinal parasites - Probable cause for high mortality of Spot-billed Pelican (Pelecanus philippensis) at Kokrebellur Community Reserve, India.

Publications

Multiple infestations of gastrointestinal parasites - Probable cause for high mortality of Spot-billed Pelican (<i>Pelecanus philippensis</i>) at Kokrebellur Community Reserve, India.

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