Ontology highlight
ABSTRACT:
SUBMITTER: Ahmadi S
PROVIDER: S-EPMC6463671 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Ahmadi Soha S Zhu Shaolong S Sharma Renu R Wu Bing B Soong Ronald R Dutta Majumdar R R Wilson Derek J DJ Simpson Andre J AJ Kraatz Heinz-Bernhard HB
ACS omega 20190315 3
Understanding the factors that give rise to tau aggregation and reactive oxygen species (ROS) is the key aspect in Alzheimer's disease pathogenesis. Microtubule (MT) binding repeats of tau protein were suggested to play a critical role in tau aggregation. Here, we show that the interaction of Cu<sup>2+</sup> with full-length MT binding repeats R1-R4 leads to the aggregation, and a Cys-based redox chemistry is critically involved in tau aggregation leading to disulfide-bridge dimerization of R2 a ...[more]