Ontology highlight
ABSTRACT:
SUBMITTER: Malfacini D
PROVIDER: S-EPMC6463727 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Malfacini Davide D Patt Julian J Annala Suvi S Harpsøe Kasper K Eryilmaz Funda F Reher Raphael R Crüsemann Max M Hanke Wiebke W Zhang Hang H Tietze Daniel D Gloriam David E DE Bräuner-Osborne Hans H Strømgaard Kristian K König Gabriele M GM Inoue Asuka A Gomeza Jesus J Kostenis Evi E
The Journal of biological chemistry 20190211 15
Transmembrane signals initiated by a range of extracellular stimuli converge on members of the Gq family of heterotrimeric G proteins, which relay these signals in target cells. Gq family G proteins comprise Gq, G11, G14, and G16, which upon activation mediate their cellular effects via inositol lipid-dependent and -independent signaling to control fundamental processes in mammalian physiology. To date, highly specific inhibition of Gq/11/14 signaling can be achieved only with FR900359 (FR) and ...[more]