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SIV progenitor evolution toward HIV: A humanized mouse surrogate model for SIVsm adaptation toward HIV-2.

ABSTRACT: How SIV progenitors evolved into deadly HIV-1 and HIV-2 following initial cross-species transmission still remains a mystery. Here, we used humanized mice as a human surrogate system to evaluate SIVsm evolution into HIV-2. Increased viral virulence to human CD4+ T cells and adaptive genetic changes were observed during serial passages.

SUBMITTER: Schmitt K

PROVIDER: S-EPMC6464631 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature

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SIV progenitor evolution toward HIV: A humanized mouse surrogate model for SIVsm adaptation toward HIV-2.

Schmitt Kimberly K Curlin James J Kumar Dipu Mohan DM Remling-Mulder Leila L Feely Stephanie S Stenglein Mark M O'Connor Shelby S Marx Preston P Akkina Ramesh R

Journal of medical primatology 20181001 5

How SIV progenitors evolved into deadly HIV-1 and HIV-2 following initial cross-species transmission still remains a mystery. Here, we used humanized mice as a human surrogate system to evaluate SIVsm evolution into HIV-2. Increased viral virulence to human CD4<sup>+</sup> T cells and adaptive genetic changes were observed during serial passages. ...[more]

PMID: 30255956

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