Ontology highlight
ABSTRACT:
SUBMITTER: Schmitt K
PROVIDER: S-EPMC6464631 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Journal of medical primatology 20181001 5
How SIV progenitors evolved into deadly HIV-1 and HIV-2 following initial cross-species transmission still remains a mystery. Here, we used humanized mice as a human surrogate system to evaluate SIVsm evolution into HIV-2. Increased viral virulence to human CD4<sup>+</sup> T cells and adaptive genetic changes were observed during serial passages. ...[more]