SWITCH 1/DYAD is a WINGS APART-LIKE antagonist that maintains sister chromatid cohesion in meiosis.
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SUBMITTER: Yang C
PROVIDER: S-EPMC6465247 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
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SWITCH 1/DYAD is a WINGS APART-LIKE antagonist that maintains sister chromatid cohesion in meiosis.
Yang Chao C Hamamura Yuki Y Sofroni Kostika K Böwer Franziska F Stolze Sara Christina SC Nakagami Hirofumi H Schnittger Arp A
Nature communications 20190415 1
Mitosis and meiosis both rely on cohesin, which embraces the sister chromatids and plays a crucial role for the faithful distribution of chromosomes to daughter cells. Prior to the cleavage by Separase at anaphase onset, cohesin is largely removed from chromosomes by the non-proteolytic action of WINGS APART-LIKE (WAPL), a mechanism referred to as the prophase pathway. To prevent the premature loss of sister chromatid cohesion, WAPL is inhibited in early mitosis by Sororin. However, Sororin homo ...[more]
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