Unknown

Dataset Information

0

KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity.


ABSTRACT: Protective immunity against pathogens depends on the efficient generation of functionally diverse effector and memory T lymphocytes. However, whether plasticity during effector-to-memory CD8+ T cell differentiation affects memory lineage specification and functional versatility remains unclear. Using genetic fate mapping analysis of highly cytotoxic KLRG1+ effector CD8+ T cells, we demonstrated that KLRG1+ cells receiving intermediate amounts of activating and inflammatory signals downregulated KLRG1 during the contraction phase in a Bach2-dependent manner and differentiated into all memory T cell linages, including CX3CR1int peripheral memory cells and tissue-resident memory cells. "ExKLRG1" memory cells retained high cytotoxic and proliferative capacity distinct from other populations, which contributed to effective anti-influenza and anti-tumor immunity. Our work demonstrates that developmental plasticity of KLRG1+ effector CD8+ T cells is important in promoting functionally versatile memory cells and long-term protective immunity.

SUBMITTER: Herndler-Brandstetter D 

PROVIDER: S-EPMC6465538 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

2018-03-01 | GSE110707 | GEO
| PRJNA434329 | ENA
| S-EPMC6820535 | biostudies-literature
| S-EPMC3703254 | biostudies-literature
| S-EPMC5783181 | biostudies-literature
| S-EPMC6981069 | biostudies-literature
| S-EPMC10213055 | biostudies-literature
| S-EPMC4959448 | biostudies-literature
| S-EPMC7415731 | biostudies-literature
| S-EPMC10323087 | biostudies-literature