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Cerebrospinal Fluid Biomarkers for the Diagnosis of Prodromal Alzheimer's Disease in Amnestic Mild Cognitive Impairment.


ABSTRACT:

Background/aims

Disease-modifying therapy for Alzheimer's disease (AD) has led to a need for biomarkers to identify prodromal AD and very early stage of AD dementia. We aimed to identify the cutoff values of cerebrospinal fluid (CSF) biomarkers for detecting prodromal AD.

Methods

We assessed 56 patients with amnestic mild cognitive impairment (aMCI) who underwent lumbar puncture. Additionally, 87 healthy elderly individuals and 34 patients with AD dementia served as controls. Positron emission tomography was performed using florbetaben as a probe. We analyzed the concentration of A?1-42, total tau protein (t-Tau), and tau protein phosphorylated at threonine 181 (p-Tau181) in CSF with INNOTEST enzyme-linked immunosorbent assay.

Results

For the detection of prodromal AD in patients with aMCI, the cutoff values of CSF A?1-42, t-Tau, and p-Tau181 were 749.5 pg/mL, 225.6 pg/mL, and 43.5 pg/mL, respectively. To discriminate prodromal AD in patients with aMCI, the t-Tau/A?1-42 and -p-Tau181/A?1-42 ratios defined cutoff values at 0.298 and 0.059, respectively.

Conclusions

CSF biomarkers are very useful tools for the differential diagnosis of prodromal AD in aMCI patients. The concentration of CSF biomarkers is well correlated with the stages of the AD spectrum.

SUBMITTER: Park JE 

PROVIDER: S-EPMC6465729 | biostudies-literature | 2019 Jan-Apr

REPOSITORIES: biostudies-literature

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Publications

Cerebrospinal Fluid Biomarkers for the Diagnosis of Prodromal Alzheimer's Disease in Amnestic Mild Cognitive Impairment.

Park Jung Eun JE   Choi Kyu Yeong KY   Kim Byeong C BC   Choi Seong-Min SM   Song Min-Kyung MK   Lee Jang Jae JJ   Kim Jahae J   Song Ho-Chun HC   Kim Hoo-Won HW   Ha Jung-Min JM   Seo Eun Hyun EH   Song Woo Keun WK   Park Sung-Gyoo SG   Lee Jung Sup JS   Lee Kun Ho KH  

Dementia and geriatric cognitive disorders extra 20190101 1


<h4>Background/aims</h4>Disease-modifying therapy for Alzheimer's disease (AD) has led to a need for biomarkers to identify prodromal AD and very early stage of AD dementia. We aimed to identify the cutoff values of cerebrospinal fluid (CSF) biomarkers for detecting prodromal AD.<h4>Methods</h4>We assessed 56 patients with amnestic mild cognitive impairment (aMCI) who underwent lumbar puncture. Additionally, 87 healthy elderly individuals and 34 patients with AD dementia served as controls. Posi  ...[more]

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