Ontology highlight
ABSTRACT:
SUBMITTER: Chandra N
PROVIDER: S-EPMC6466042 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Chandra Naresh N Liu Yan Y Liu Jing-Xia JX Frängsmyr Lars L Wu Nian N Silva Lisete M LM Lindström Mona M Chai Wengang W Pedrosa Domellöf Fatima F Feizi Ten T Arnberg Niklas N
Viruses 20190312 3
Glycans on plasma membranes and in secretions play important roles in infection by many viruses. Species D human adenovirus type 37 (HAdV-D37) is a major cause of epidemic keratoconjunctivitis (EKC) and infects target cells by interacting with sialic acid (SA)-containing glycans via the fiber knob domain of the viral fiber protein. HAdV-D37 also interacts with sulfated glycosaminoglycans (GAGs), but the outcome of this interaction remains unknown. Here, we investigated the molecular requirements ...[more]