Ontology highlight
ABSTRACT:
SUBMITTER: Li C
PROVIDER: S-EPMC6466124 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Li Chunfu C Zhang Hongliang H Ji Lina L Wang Xiao X Wen Yongjun Y Li Guangpeng G Fu Zhen F ZF Yang Yang Y
Viruses 20190304 3
Previous studies have shown that wild-type (wt) rabies virus (RABV) evades the host immune response by restricting expression of glycoprotein (G), which blocks activation of dendritic cells (DCs) and induces production of virus-neutralizing antibodies (VNAs). In the present study, wt RABVs not only restricted G expression but also reduced incorporation of G into mature virions compared with laboratory-adapted viruses. A recombinant RABV expressing triple G was used to further determine whether G ...[more]