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Manganese-Catalyzed ?-Alkylation of Ketones, Esters, and Amides Using Alcohols.

ABSTRACT: Herein we report the manganese-catalyzed C-C bond-forming reactions via ?-alkylation of ketones, amides, and esters, using primary alcohols. ?-Alkylation of secondary alcohols by primary alcohols to obtain ?-alkylated ketones is also reported. The reactions are catalyzed by a ( i Pr-PNP)Mn(H)(CO)2 pincer complex under mild conditions in the presence of (catalytic) base liberating water (and H2 in the case of secondary alcohol alkylation) as the sole byproduct.

SUBMITTER: Chakraborty S 

PROVIDER: S-EPMC6466737 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Manganese-Catalyzed α-Alkylation of Ketones, Esters, and Amides Using Alcohols.

Chakraborty Subrata S   Daw Prosenjit P   Ben David Yehoshoa Y   Milstein David D  

ACS catalysis 20181002 11

Herein we report the manganese-catalyzed C-C bond-forming reactions via α-alkylation of ketones, amides, and esters, using primary alcohols. β-Alkylation of secondary alcohols by primary alcohols to obtain α-alkylated ketones is also reported. The reactions are catalyzed by a ( <sup><i>i</i></sup> Pr-PNP)Mn(H)(CO)<sub>2</sub> pincer complex under mild conditions in the presence of (catalytic) base liberating water (and H<sub>2</sub> in the case of secondary alcohol alkylation) as the sole byprod  ...[more]

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