Chalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T-cell Acute Lymphoblastic Leukemia.
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ABSTRACT:
SUBMITTER: Quaglio D
PROVIDER: S-EPMC6466818 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Publications
Chalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T-cell Acute Lymphoblastic Leukemia.
Quaglio Deborah D Zhdanovskaya Nadezda N Tobajas Gloria G Cuartas Viviana V Balducci Silvia S Christodoulou Michael S MS Fabrizi Giancarlo G Gargantilla Marta M Priego Eva-María EM Carmona Pestaña Álvaro Á Passarella Daniele D Screpanti Isabella I Botta Bruno B Palermo Rocco R Mori Mattia M Ghirga Francesca F Pérez-Pérez María-Jesús MJ
ACS medicinal chemistry letters 20190226 4
Based on hit-likeness and chemical diversity, a number of chalcones and chalcone-mimetic compounds were selected as putative Notch inhibitors. The evaluation of the antiproliferative effect combined with the inhibition of Notch1 expression in KOPTK1 cell line identified compound <b>18</b>, featuring a tetrahydronaphthalene-based scaffold, as a new promising Notch-blocking agent. ...[more]
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