Dataset Information

Impact of HLA Allele-KIR Pairs on HIV Clinical Outcome in South Africa.

ABSTRACT:

Background

HLA class I contributes to HIV immune control through antigen presentation to cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. In contrast to investigations of CTL, studies of NK cells in HIV control through HLA-killer immunoglobulin-like receptor (KIR) interactions remain sparse in African cohorts.

Methods

Treatment-naive, chronically HIV-infected adults (N = 312) were recruited from South Africa, and the effects of HLA-KIR pairs on clinical outcome were analyzed.

Results

There was no significant difference in viral load among all subjects with HLA alleles from the HLA-C1 group (P = .1). However, differences in HLA-C type significantly influenced viremia among 247 KIR2DL3 positives (P = .04), suggesting that specific HLA-KIR interactions contribute to immune control. Higher viral load (P = .02) and lower CD4+ T-cell counts (P = .008) were observed in subjects with HLA-C*16:01+KIR2DL3+. Longitudinal analysis showed more rapid progression to AIDS among HLA-C*16:01+KIR2DL3+ subjects (adjusted hazard ratio 1.9, P = .03) than those without this genotype, independent of CD4+ T-cell count and viral load.

Conclusions

These results highlight the existence of unique anti-HIV innate immunity within distinct populations and the contribution of KIR on NK cells and some CTLs to the well-described HLA-mediated impact on HIV disease progression.

SUBMITTER: Mori M

PROVIDER: S-EPMC6467198 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Publications

Impact of HLA Allele-KIR Pairs on HIV Clinical Outcome in South Africa.

Mori Masahiko M Leitman Ellen E Walker Bruce B Ndung'u Thumbi T Carrington Mary M Goulder Philip P

The Journal of infectious diseases 20190401 9

<h4>Background</h4>HLA class I contributes to HIV immune control through antigen presentation to cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. In contrast to investigations of CTL, studies of NK cells in HIV control through HLA-killer immunoglobulin-like receptor (KIR) interactions remain sparse in African cohorts.<h4>Methods</h4>Treatment-naive, chronically HIV-infected adults (N = 312) were recruited from South Africa, and the effects of HLA-KIR pairs on clinical outcome were a ...[more]

PMID: 30520960

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Dataset Information

Impact of HLA Allele-KIR Pairs on HIV Clinical Outcome in South Africa.

Background

Methods

Results

Conclusions

Publications

Impact of HLA Allele-KIR Pairs on HIV Clinical Outcome in South Africa.

Similar Datasets

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