Ontology highlight
ABSTRACT:
SUBMITTER: Er EE
PROVIDER: S-EPMC6467203 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Nature cell biology 20180723 8
Metastatic seeding by disseminated cancer cells principally occurs in perivascular niches. Here, we show that mechanotransduction signalling triggered by the pericyte-like spreading of disseminated cancer cells on host tissue capillaries is critical for metastatic colonization. Disseminated cancer cells employ L1CAM (cell adhesion molecule L1) to spread on capillaries and activate the mechanotransduction effectors YAP (Yes-associated protein) and MRTF (myocardin-related transcription factor). Th ...[more]