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MTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors.

ABSTRACT: The mechanistic target of rapamycin complex 1 (mTORC1) has been reported to be necessary for metabotropic glutamate receptor-mediated long-term depression (mGluR-LTD). Here we found that mTORC1-deficient mice exhibit normal hippocampal mGluR-LTD and associated behaviors. Moreover, rapamycin blocks mGluR-LTD in mTORC1-deficient mice. However, both rapamycin and mGluR activation regulate mTOR complex 2 (mTORC2) activity, and mTORC2-deficient mice show impaired mGluR-LTD and associated behaviors. Thus, mTORC2 is a major regulator of mGluR-LTD.

SUBMITTER: Zhu PJ

PROVIDER: S-EPMC6467217 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature

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mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors.

Zhu Ping Jun PJ Chen Chien-Ju CJ Mays Jacqunae J Stoica Loredana L Costa-Mattioli Mauro M

Nature neuroscience 20180521 6

The mechanistic target of rapamycin complex 1 (mTORC1) has been reported to be necessary for metabotropic glutamate receptor-mediated long-term depression (mGluR-LTD). Here we found that mTORC1-deficient mice exhibit normal hippocampal mGluR-LTD and associated behaviors. Moreover, rapamycin blocks mGluR-LTD in mTORC1-deficient mice. However, both rapamycin and mGluR activation regulate mTOR complex 2 (mTORC2) activity, and mTORC2-deficient mice show impaired mGluR-LTD and associated behaviors. T ...[more]

PMID: 29786082

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