Ontology highlight
ABSTRACT:
SUBMITTER: Membreno R
PROVIDER: S-EPMC6467224 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Membreno Rosemery R Cook Brendon E BE Fung Kimberly K Lewis Jason S JS Zeglis Brian M BM
Molecular pharmaceutics 20180308 4
Pretargeted radioimmunotherapy (PRIT) based on the inverse electron demand Diels-Alder (IEDDA) reaction between tetrazine (Tz) and trans-cyclooctene (TCO) represents a promising strategy for leveraging the affinity and specificity of antibodies without their pharmacokinetic drawbacks. Herein, we present an investigation of the in vivo efficacy and dosimetry of a PRIT strategy for colorectal carcinoma based on the ligation between a <sup>177</sup>Lu-labeled Tz radioligand (<sup>177</sup>Lu-DOTA-P ...[more]