Dataset Information

Survivin at a glance.

ABSTRACT: Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upregulated in most, if not all cancers; consequently, it has received significant attention as a potential oncotherapeutic target. In this Cell Science at a Glance article and accompanying poster, we summarise our knowledge of survivin 21?years on from its initial discovery. We describe the structure, expression and function of survivin, highlight its interactome and conclude by describing anti-survivin strategies being trialled.

SUBMITTER: Wheatley SP

PROVIDER: S-EPMC6467487 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Survivin at a glance.

Wheatley Sally P SP Altieri Dario C DC

Journal of cell science 20190404 7

Survivin (also known as BIRC5) is an evolutionarily conserved eukaryotic protein that is essential for cell division and can inhibit cell death. Normally it is only expressed in actively proliferating cells, but is upregulated in most, if not all cancers; consequently, it has received significant attention as a potential oncotherapeutic target. In this Cell Science at a Glance article and accompanying poster, we summarise our knowledge of survivin 21 years on from its initial discovery. We descr ...[more]

PMID: 30948431

Dataset Information

Survivin at a glance.

Publications

Survivin at a glance.

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