Ontology highlight
ABSTRACT:
SUBMITTER: Romenskaia I
PROVIDER: S-EPMC6467731 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Romenskaia Irina I DeAntonis Christine M CM Presnyak Vladimir V Schultz Joshua R JR Ryan Robert O RO
Biochemical and biophysical research communications 20190320 2
Despite its exceptionally low circulating concentration, apolipoprotein (apo) A-V is a potent modulator of plasma triacylglycerol levels. The secretion efficiency of nascent apoA-V was investigated in cultured cells transfected with mRNA. Following transfection of HepG2 cells with wild type apoA-V mRNA, apoA-V protein was detectable in cell lysates by 6 h. At 24 h post transfection, evidence of apoA-V secretion into media was obtained, although most apoA-V was recovered in the cell lysate fracti ...[more]