Ontology highlight
ABSTRACT:
SUBMITTER: Liao W
PROVIDER: S-EPMC6467776 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Cancer cell 20190321 4
The biological functions and mechanisms of oncogenic KRAS<sup>G12D</sup> (KRAS<sup>∗</sup>) in resistance to immune checkpoint blockade (ICB) therapy are not fully understood. We demonstrate that KRAS<sup>∗</sup> represses the expression of interferon regulatory factor 2 (IRF2), which in turn directly represses CXCL3 expression. KRAS<sup>∗</sup>-mediated repression of IRF2 results in high expression of CXCL3, which binds to CXCR2 on myeloid-derived suppressor cells and promotes their migration t ...[more]