Ontology highlight
ABSTRACT:
SUBMITTER: Kunkle T
PROVIDER: S-EPMC6467803 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Kunkle Trent T Abdeen Sanofar S Salim Nilshad N Ray Anne-Marie AM Stevens Mckayla M Ambrose Andrew J AJ Victorino José J Park Yangshin Y Hoang Quyen Q QQ Chapman Eli E Johnson Steven M SM
Journal of medicinal chemistry 20181115 23
We recently reported the identification of a GroEL/ES inhibitor (1, N-(4-(benzo[ d]thiazol-2-ylthio)-3-chlorophenyl)-3,5-dibromo-2-hydroxybenzamide) that exhibited in vitro antibacterial effects against Staphylococcus aureus comparable to vancomycin, an antibiotic of last resort. To follow up, we have synthesized 43 compound 1 analogs to determine the most effective functional groups of the scaffold for inhibiting GroEL/ES and killing bacteria. Our results identified that the benzothiazole and h ...[more]