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Cu-Catalyzed Cross-Dehydrogenative ortho-Aminomethylation of Phenols.

ABSTRACT: A highly selective Cu^II -catalyzed cross-dehydrogenative ortho-aminomethylation of phenols with aniline derivatives is described. The corresponding C(sp² )-C(sp³ ) coupling products were obtained in moderate to excellent yields under mild reaction conditions and with a broad substrate scope. A radical mechanism is proposed.

SUBMITTER: Yu C

PROVIDER: S-EPMC6468272 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

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Cu-Catalyzed Cross-Dehydrogenative ortho-Aminomethylation of Phenols.

Yu Congjun C Patureau Frederic W FW

Angewandte Chemie (International ed. in English) 20180801 36

A highly selective CuII -catalyzed cross-dehydrogenative ortho-aminomethylation of phenols with aniline derivatives is described. The corresponding C(sp2 )-C(sp3 ) coupling products were obtained in moderate to excellent yields under mild reaction conditions and with a broad substrate scope. A radical mechanism is proposed. ...[more]

PMID: 29931717

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