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Nucleus-Targeted Organoiridium-Albumin Conjugate for Photodynamic Cancer Therapy.

ABSTRACT: An organoiridium-albumin bioconjugate (Ir1-HSA) was synthesized by reaction of a pendant maleimide ligand with human serum albumin. The phosphorescence of Ir1-HSA was enhanced significantly compared to parent complex Ir1. The long phosphorescence lifetime and high 1 O2 quantum yield of Ir1-HSA are highly favorable properties for photodynamic therapy. Ir1-HSA mainly accumulated in the nucleus of living cancer cells and showed remarkable photocytotoxicity against a range of cancer cell lines and tumor spheroids (light IC50 ; 0.8-5??m, photo-cytotoxicity index PI=40-60), while remaining non-toxic to normal cells and normal cell spheroids, even after photo-irradiation. This nucleus-targeting organoiridium-albumin is a strong candidate photosensitizer for anticancer photodynamic therapy.

SUBMITTER: Zhang P

PROVIDER: S-EPMC6468315 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Nucleus-Targeted Organoiridium-Albumin Conjugate for Photodynamic Cancer Therapy.

Zhang Pingyu P Huang Huaiyi H Banerjee Samya S Clarkson Guy J GJ Ge Chen C Imberti Cinzia C Sadler Peter J PJ

Angewandte Chemie (International ed. in English) 20190121 8

An organoiridium-albumin bioconjugate (Ir1-HSA) was synthesized by reaction of a pendant maleimide ligand with human serum albumin. The phosphorescence of Ir1-HSA was enhanced significantly compared to parent complex Ir1. The long phosphorescence lifetime and high <sup>1</sup> O<sub>2</sub> quantum yield of Ir1-HSA are highly favorable properties for photodynamic therapy. Ir1-HSA mainly accumulated in the nucleus of living cancer cells and showed remarkable photocytotoxicity against a range of c ...[more]

PMID: 30552796

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