Radiation Increases Functional KCa3.1 Expression and Invasiveness in Glioblastoma.
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ABSTRACT:
SUBMITTER: D'Alessandro G
PROVIDER: S-EPMC6468446 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
Radiation Increases Functional KCa3.1 Expression and Invasiveness in Glioblastoma.
D'Alessandro Giuseppina G Monaco Lucia L Catacuzzeno Luigi L Antonangeli Fabrizio F Santoro Antonio A Esposito Vincenzo V Franciolini Fabio F Wulff Heike H Limatola Cristina C
Cancers 20190226 3
Glioblastoma (GBM) is a deadly brain tumor, with fast recurrence even after surgical intervention, radio- and chemotherapies. One of the reasons for relapse is the early invasion of surrounding brain parenchyma by GBM, rendering tumor eradication difficult. Recent studies demonstrate that, in addition to eliminate possible residual tumoral cells after surgery, radiation stimulates the infiltrative behavior of GBM cells. The intermediate conductance of Ca<sup>2+</sup>-activated potassium channels ...[more]
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