Circulating MicroRNA Biomarkers for Lung Cancer Detection in East Asian Populations.

ABSTRACT:

Background

Lung cancer (LC) is the leading cause of cancer-related death in Eastern Asia. The prognosis of LC highly depends on tumor stages and early detection could substantially reduce LC mortality. Accumulating evidence suggested that circulating miRNAs in plasma or serum may have applications in early LC detection. We thus conducted a systematic literature review on the diagnostic value of miRNAs markers for LC in East Asian populations.

Methods

PubMed and ISI Web of Knowledge were searched to retrieve relevant articles published up to 17 September 2018. Information on study design, population characteristics, investigated miRNAs and diagnostic accuracy (including sensitivity, specificity and area under the curve (AUC)) were independently extracted by two reviewers.

SUBMITTER: Yu H 

PROVIDER: S-EPMC6468694 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature