Teriparatide for treatment of patients with bisphosphonate-associated atypical fracture of the femur.

ABSTRACT: The Fracture Improvement with Teriparatide (Fix-IT) study randomized 13 women with an atypical femur fracture to immediate vs delayed teriparatide therapy; all were followed for 12 months. Results suggested a trend for superior healing and lesser bone mineral density declines in the immediate vs delayed group with no differences in adverse events.

Purpose

Little clinical data are available on the use of teriparatide for the treatment of bisphosphonate-associated atypical femur fractures (AFF). The goal of the Fix-IT study was to determine if immediate therapy with teriparatide was superior for fracture healing after an AFF compared to a 6-month delay in teriparatide therapy.

Methods

This randomized pilot clinical trial included 13 women with an AFF who were randomized to imme

SUBMITTER: Greenspan SL 

PROVIDER: S-EPMC6468986 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature