Ontology highlight
ABSTRACT:
SUBMITTER: Sikander M
PROVIDER: S-EPMC6469021 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Sikander Mohammed M Malik Shabnam S Chauhan Neeraj N Khan Parvez P Kumari Sonam S Kashyap Vivek Kumar VK Khan Sheema S Ganju Aditya A Halaweish Fathi T FT Yallapu Murali M MM Jaggi Meena M Chauhan Subhash C SC
Cancers 20190314 3
Prostate cancer (PrCa) metastasis is the major cause of mortality and morbidity among men. Metastatic PrCa cells are typically adopted for aberrant glucose metabolism. Thus, chemophores that reprogram altered glucose metabolic machinery in cancer cells can be useful agent for the repression of PrCa metastasis. Herein, we report that cucurbitacin D (Cuc D) effectively inhibits glucose uptake and lactate production in metastatic PrCa cells via modulating glucose metabolism. This metabolic shift by ...[more]