Ontology highlight
ABSTRACT:
SUBMITTER: Schirrmacher R
PROVIDER: S-EPMC6469173 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Schirrmacher Ralf R Bailey Justin J JJ Mossine Andrew V AV Scott Peter J H PJH Kaiser Lena L Bartenstein Peter P Lindner Simon S Kaplan David R DR Kostikov Alexey A Fricker Gert G Mahringer Anne A Rosa-Neto Pedro P Schirrmacher Esther E Wängler Carmen C Wängler Björn B Thiel Alexander A Soucy Jean-Paul JP Bernard-Gauthier Vadim V
Pharmaceuticals (Basel, Switzerland) 20190103 1
The tropomyosin receptor kinases family (TrkA, TrkB, and TrkC) supports neuronal growth, survival, and differentiation during development, adult life, and aging. TrkA/B/C downregulation is a prominent hallmark of various neurological disorders including Alzheimer's disease (AD). Abnormally expressed or overexpressed full-length or oncogenic fusion TrkA/B/C proteins were shown to drive tumorigenesis in a variety of neurogenic and non-neurogenic human cancers and are currently the focus of intensi ...[more]