Association of the MMP-9 polymorphism and ischemic stroke risk in southern Chinese Han population.

ABSTRACT: BACKGROUND:Stroke is a serious cardiovascular disease and is also the leading cause of long-term disability in developing and developed countries. Because matrix metalloproteinase-9 (MMP-9) is associated with the risk of many cardiovascular diseases, we investigated the relationship between single nucleotide polymorphisms (SNPs) in MMP-9 and the risk of Ischemic stroke (IS) in a southern Chinese Han population. METHODS:This study included 250 stroke patients and 250 healthy controls. Genotyping was performed using the Agena MassARRAY system, and chi-squared tests and genetic models were used to evaluate the associations between MMP-9 SNPs and the risk of IS. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression adjusted for age. RESULTS:Polymorphism rs3787268 was associated with increased the risk of IS. Specifically, the genotype "G/A" significantly correlated with IS risk in the co-dominant model [odds ratio (OR)?=?1.62; 95% confidence interval (CI)?=?1.10-2.41; p?=?0.035)], while genotypes "G/A" and "A/A" may increase the risk of IS based on the dominant model (OR?=?1.62; 95% CI?=?1.12-2.35; p?=?0.0097). This SNP was also significantly associated with IS risk in the log-additive model (OR?=?1.33; 95% CI?=?1.03-1.70; p?=?0.026). Conversely, haplotype "C/G" appears to reduce the risk of IS (OR?=?0.71; 95% CI?=?0.54-0.95; p?=?0.019). CONCLUSIONS:Our study showed that the rs3787268 locus in the MMP-9 gene may increase risk of IS in a southern Chinese Han population and thus provide insight into the IS pathogenesis.

SUBMITTER: Gao N 

PROVIDER: S-EPMC6469199 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature