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Visit-to-visit fasting plasma glucose variability is an important risk factor for long-term changes in left cardiac structure and function in patients with type 2 diabetes.


ABSTRACT: BACKGROUND:To investigate the effect of visit-to-visit fasting plasma glucose (FPG) variability on the left cardiac structure and function in patients with type 2 diabetes mellitus (T2DM). METHODS:In this prospective cohort study, 455 T2DM patients were included and follow-up for a median of 4.7 years. FPG measured on every hospital visit was collected. FPG variability was calculated by its coefficient of variation (CV-FPG). Left cardiac structure and function were assessed using echocardiography at baseline and after follow-up. Multivariable linear regression analyses were used to estimate the effect of FPG variability on the annualized changes in left cardiac structure and function. Subgroup analysis stratified by mean HbA1c levels (

SUBMITTER: Tang X 

PROVIDER: S-EPMC6469221 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Visit-to-visit fasting plasma glucose variability is an important risk factor for long-term changes in left cardiac structure and function in patients with type 2 diabetes.

Tang Xixiang X   Zhong Junlin J   Zhang Hui H   Luo Yanting Y   Liu Xing X   Peng Long L   Zhang Yanling Y   Qian Xiaoxian X   Jiang Boxiong B   Liu Jinlai J   Li Suhua S   Chen Yanming Y  

Cardiovascular diabetology 20190416 1


<h4>Background</h4>To investigate the effect of visit-to-visit fasting plasma glucose (FPG) variability on the left cardiac structure and function in patients with type 2 diabetes mellitus (T2DM).<h4>Methods</h4>In this prospective cohort study, 455 T2DM patients were included and follow-up for a median of 4.7 years. FPG measured on every hospital visit was collected. FPG variability was calculated by its coefficient of variation (CV-FPG). Left cardiac structure and function were assessed using  ...[more]

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