Ontology highlight
ABSTRACT:
SUBMITTER: Yuan Y
PROVIDER: S-EPMC6470170 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Yuan Yukun Y O'Malley Heather A HA Smaldino Melissa A MA Bouza Alexandra A AA Hull Jacob M JM Isom Lori L LL
Scientific reports 20190417 1
Dravet syndrome (DS) is a catastrophic developmental and epileptic encephalopathy characterized by severe, pharmacoresistant seizures and the highest risk of Sudden Unexpected Death in Epilepsy (SUDEP) of all epilepsy syndromes. Here, we investigated the time course of maturation of neuronal GABAergic signaling in the Scn1b<sup>-/-</sup> and Scn1a<sup>+/-</sup> mouse models of DS. We found that GABAergic signaling remains immature in both DS models, with a depolarized reversal potential for GABA ...[more]