Ontology highlight
ABSTRACT:
SUBMITTER: Azushima K
PROVIDER: S-EPMC6470237 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Azushima Kengo K Uneda Kazushi K Wakui Hiromichi H Ohki Kohji K Haruhara Kotaro K Kobayashi Ryu R Haku Sona S Kinguchi Sho S Yamaji Takahiro T Minegishi Shintaro S Ishigami Tomoaki T Yamashita Akio A Tamura Kouichi K
Scientific reports 20190417 1
The underlying pathogenesis of chronic kidney disease involves an activated renin-angiotensin system and systemic inflammation which ultimately develop renal injury. Rikkunshito (RKT) has been reported to exert anti-fibrotic and anti-inflammatory effects through enhancement of ghrelin signaling pathway. In this study, we investigated the effects of RKT on renal fibrosis and inflammation in angiotensin II (Ang II)-induced renal injury model. Ang II-infused mice exhibited hypertension, cardiac hyp ...[more]