Ontology highlight
ABSTRACT:
SUBMITTER: Pollard CM
PROVIDER: S-EPMC6470638 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Pollard Celina M CM Desimine Victoria L VL Wertz Shelby L SL Perez Arianna A Parker Barbara M BM Maning Jennifer J McCrink Katie A KA Shehadeh Lina A LA Lymperopoulos Anastasios A
International journal of molecular sciences 20190320 6
Cardiac β₂-adrenergic receptors (ARs) are known to inhibit collagen production and fibrosis in cardiac fibroblasts and myocytes. The β₂AR is a Gs protein-coupled receptor (GPCR) and, upon its activation, stimulates the generation of cyclic 3',5'-adenosine monophosphate (cAMP). cAMP has two effectors: protein kinase A (PKA) and the exchange protein directly activated by cAMP (Epac). Epac1 has been shown to inhibit cardiac fibroblast activation and fibrosis. Osteopontin (OPN) is a ubiquitous pro-i ...[more]