Ontology highlight
ABSTRACT:
SUBMITTER: Hande M
PROVIDER: S-EPMC6470670 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20190326 6
2'-<i>O</i>-Methylribo phosphorothioate oligonucleotides incorporating cyclopalladated benzylamine conjugate groups at their 5'-termini have been prepared and their ability to hybridize with a designated target sequence was assessed by conventional UV melting experiments. The oligonucleotides were further examined in splice-switching experiments in human cervical cancer (HeLa Luc/705), human liver (HuH7_705), and human osteosarcoma (U-2 OS_705) reporter cell lines. Melting temperatures of duplex ...[more]