Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen T
PROVIDER: S-EPMC6471062 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Nguyen Thanh T Ho Minh M Kim Kyungmin K Yun Sun-Il SI Mizar Pushpak P Easton James W JW Lee Seung Seo SS Kim Kyeong Kyu KK
Molecules (Basel, Switzerland) 20190319 6
Development of inhibitors for ubiquitin pathway has been suggested as a promising strategy to treat several types of cancers, which has been showcased by recent success of a series of novel anticancer drugs based on inhibition of ubiquitin pathways. Although the druggability of enzymes in ubiquitin pathways has been demonstrated, ubiquitin itself, the main agent of the pathway, has not been targeted. Whereas conventional enzyme inhibitors are used to silence the ubiquitination or reverse it, the ...[more]