Ontology highlight
ABSTRACT:
SUBMITTER: El-Naggar M
PROVIDER: S-EPMC6471095 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
El-Naggar Mohamed M Sallam Hanan A HA Shaban Safaa S SS Abdel-Wahab Salwa S SS E Amr Abd El-Galil AE Azab Mohammad E ME Nossier Eman S ES Al-Omar Mohamed A MA
Molecules (Basel, Switzerland) 20190318 6
A new series of 5-(3,5-dinitrophenyl)-1,3,4-thiadiazole derivatives were prepared and evaluated for their in vitro antimicrobial, antitumor, and DHFR inhibition activity. Compounds <b>9</b>, <b>10</b>, <b>13</b>, and <b>16</b> showed strong and broad-spectrum antimicrobial activity comparable to Amoxicillin and Fluconazole as positive antibiotic and antifungal controls, respectively. Compounds <b>6</b>, <b>14</b>, and <b>15</b> exhibited antitumor activity against four human cancer cell lines, C ...[more]