Ontology highlight
ABSTRACT:
SUBMITTER: Zhao H
PROVIDER: S-EPMC6471201 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Zhao Hongchuan H Sun Pu P Guo Wei W Wang Yi Y Zhang Ao A Meng Linghua L Ding Chunyong C
Molecules (Basel, Switzerland) 20190318 6
There is great interest in developing small molecules agents capable of reversing tumor immune escape to restore the body's immune system. As an immunosuppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO-1) is considered a promising target for oncology immunotherapy. Currently, none of IDO-1 inhibitors have been launched for clinical practice yet. Thus, the discovery of new IDO-1 inhibitors is still in great demand. Herein, a series of diverse <i>ortho</i>-naphthaquinone containing natural pro ...[more]