In Situ Characterization of Hfq Bacterial Amyloid: A Fourier-Transform Infrared Spectroscopy Study.
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ABSTRACT:
SUBMITTER: Partouche D
PROVIDER: S-EPMC6471401 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
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<i>In Situ</i> Characterization of Hfq Bacterial Amyloid: A Fourier-Transform Infrared Spectroscopy Study.
Partouche David D Militello Valeria V Gomez-Zavaglia Andrea A Wien Frank F Sandt Christophe C Arluison Véronique V
Pathogens (Basel, Switzerland) 20190318 1
Hfq is a bacterial protein that regulates gene expression at the post-transcriptional level in Gram-negative bacteria. We have previously shown that <i>Escherichia coli</i> Hfq protein, and more precisely its C-terminal region (CTR), self-assembles into an amyloid-like structure in vitro. In the present work, we present evidence that Hfq unambiguously forms amyloid structures also in vivo. Taking into account the role of this protein in bacterial adaptation and virulence, our work opens possibil ...[more]
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